Clinical Trials


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ISPPC is not only devoted to delivering the best in pain care & spine and musculoskeletal medicine, but also to furthering the scope of what is medically possible. Our currently enrolling clinical trials are listed below. These studies are designed to help provide you with pain relief at little to no cost with the possibility of modest compensation for time and travel. Consider enrolling in a clinical trial today, and together we will push the boundaries of science and medicine.

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What are clinical trials?

Clinical trials are research studies aimed at evaluating the success of new treatments. Prior to a drug or device being approved for general use, it must go through rigorous testing to ensure it is safe and effective in people. Part of this process is reviewing data and having safety monitoring boards track the progress of the trial. 

The physicians and research team at ISPPC maintain an avid interest in research and our portfolio includes many clinical trials focused on medication injections, radiofrequency, and spinal cord stimulation. Participants are carefully selected for our clinical trials, and the team at ISPPC will make sure you understand the scope of the study and what you can expect throughout the duration of the trial. 



Key Eligibility Criteria



Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT)

This prospective, minimal risk, multi-centered, randomized control study is being conducted to document the comparative effectiveness and safety of peripheral nerve stimulation (PNS) plus conventional medical management (CMM) versus CMM alone in the treatment of chronic, intractable peripheral neuralgia of post-traumatic or post-surgical origin. This is a prospective, minimal risk, multi-center, randomized control trial.

- 18-80 years old

- Diagnosed post-surgical/post-traumatic peripheral neuralgia in the low back, shoulder or knee and foot (including ankle)

- Chronic (at least 6 months duration), intractable peripheral neuropathic pain, exclusive of the craniofacial region

Nalu Medical, Inc.

Mehul Desai

A Prospective, Open-label, Long-term, Multi-center, Registry to Assess the Safety and Efficacy of the Bioness StimRouter Neuromodulation System in Subjects with Chronic Pain of Peripheral Nerve Origin

This registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes, health-related quality of life, concomitant medical use, and subject's impression of improvement.

- ≥18 years

- Chronic pain of peripheral nerve origin

Bioness, Inc.

Mehul Desai

A Randomized, Controlled, Multicenter Trial of Percutaneous Peripheral Nerve Stimulation (PNS) for the Treatment of Back Pain

This is a randomized, controlled, multicenter study comparing standard of care treatments for back pain to electrical stimulation. This study will use a device called the SPRINT Peripheral Nerve Stimulation (PNS) System. The device is cleared by the FDA for up to 60 days of use for the relief of chronic or acute pain (including back pain).

- 21 to 75 years old

- Chronic low back pain

SPR Therapeutics, Inc.

Mehul Desai

Discogenic Low Back Pain Registry

This is a prospective registry intended to complement and integrate data collected in ongoing randomized-controlled clinical studies to aid in establishing payor coverage in the United States (US) for VIA Disc NP with real-world data. This registry will further assist in establishing a health economics argument for use of VIA Disc NP in medical facilities for US payors and provide real-world data to support ongoing quality for care initiatives.

- ≥18 years

- Diagnosed discogenic low back pain

VIVEX Biologics, Inc.

Mehul Desai

A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis

This is a double-blind, randomized, placebo controlled study to evaluate the efficacy and safety of JointStem, autologous adipose tissue derived mesenchymal stem cells (AdMSC), in patients diagnosed as knee osteoarthritis.

- ≥18 years

- Diagnosed knee osteoarthritis

Nature Cell Co., Ltd.

Mehul Desai

Spinal Cord Stimulation in the Treatment of Chronic, Intractable Pain using the Nalu™ Neurostimulation System (nPower™-US)

This is a prospective registry study to confirm the efficacy and safety of the Nalu Neurostimulation System in adult subjects with chronic pain in the legs and back. The study will gather real-world data to assess performance and functionality to improve future systems.

- 21 to 80 years old

- Chronic (at least 6 months duration), intractable neuropathic pain of legs and/or back

Nalu Medical, Inc.

Mehul Desai

ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation (RESTORE)

This is a prospective, randomized study evaluating the safety and efficacy of ReActiv8 for the treatment of adults with chronic low back pain when used in conjunction with optimal medical management (OMM).

- ≥21 years

- Intractable Chronic Low Back Pain that has persisted >6 months resulting in pain most of the days in the past 12 months

Mainstay Medical

Mehul Desai

An Interventional, Phase III, Double-blind, Randomized, Controlled, Parallel-group, Multi-site, Clinical Trial Evaluating the Efficacy and Safety of Qutenza in Subjects With Post-surgical Neuropathic Pain

This is a double-blind, randomized, controlled study to confirm the efficacy and safety of repeated topical application of Qutenza (capsaicin 8% topical system) versus low-dose capsaicin control (capsaicin 0.04% topical system) in subjects with moderate to severe postsurgical neuropathic pain (PSNP).

- ≥18 years

- Documented diagnosis of post surgical neuropathic pain (PSNP)

- Documented diagnosis of probable or definite PSNP

Averitas Pharma, Inc.

Mehul Desai

Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain (Saol 1010-01)

This is a double-blind, placebo-controlled, single ascending dose escalation study to assess the safety and efficacy of single treatment exposure of an injectable formulation of SL-1002 for the treatment of knee pain associated with osteoarthritis.

- ≥35 years

- Diagnosis of chronic knee pain resulting from osteoarthritis (greater than 6 months)

- Currently experiencing continued pain despite receiving at least 3 months of conservative treatments

Saol Therapeutics, Inc.

Mehul Desai


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